商明
Ming Shang
长聘教轨副教授
Email：shangsjtu@sjtu.edu.cn
教育背景
2006-2010 复旦大学，理学学士
2011-2016 中科院上海有机所，理学博士
工作经历
2016-2017 美国波士顿学院，博士后
2017-2020 美国斯克里普斯研究所，博士后
2021-至今 上海交通大学变革性分子前沿科学中心，长聘教轨副教授
研究方向
核酸合成与修饰
核酸药物开发
学术任职、荣誉与获奖
2023-2025年度威立 Wiley 中国杰出作者奖（2026）
上海市青年科技35人引领计划 (2022)
Thieme Chemistry Journals Award (2022)
代表性论文专著
Fang, S.-S.; Sun, G.-D.; Liu, J.-W.; Li, M.-H.; Xie, T.; Yuan, K.-N.; Yao, H-Q.; Cai, Y.-M.; Fan, C.; Shang, M.* “Multifunctional Organocatalysts Enable Stereoselective Synthesis of Phosphorothioate Oligonucleotides.” Nat. Catal. 2026, in press.
Yuan, K.-N., Zhuang, H.-J.; Jiang, Y.-L.; Cai, Y.-M.; Xu, B.; Shang, M.* “Photoelectrocatalyzed Alkylation of Phosphonites via Direct Decarboxylative C(sp3)-P Coupling” Angew. Chem. Int. Ed. 2026, e24814.
Cai, Y.-M.; Yuan, K.-N.; Huang, P.-Y.; Xie, T.; Shang, M.* “Quaternary Carbon Centers via Electrochemical Direct Dehydroxylative Alkylation.” Angew. Chem. Int. Ed. 2026, e20816.
Wang, J.-B.; Fang, S.-S.; Shen, Y.; Liu, X.-T.; Li, M.-H.; Ying, J.-J.; Kong, W.-J.;* Shang, M.* “Enantioselective Nickel-Catalyzed Reductive Decarboxylative C(sp3)-C(sp2) Cross-Coupling of Malonic Acid Derivatives.” Chin. J. Chem. 2026, 1591.
Wang, J.-B.; Lv, J.; Bankar, S.; Fang, S.-S.; Shang, M.* “Stereoselective Synthesis of P-Stereogenic Nucleotide Prodrugs and Oligonucleotides.” Chem. Soc. Rev. 2025, 54, 9370.
Yao, H.-Q.; Cai, Y.-M.; Xie, T.; Lv, J.; Fang, S.-S.; Li, M.-H.; Shang, M.* “Modular Access to P(V)-Stereogenic Compounds via Cu-Catalyzed Desymmetrization of (Thio)Phosphonic Dichlorides.” Angew. Chem. Int. Ed. 2025, e20250980.
Yuan, K.-N.; Xie, T.; Wang, J.-B.; Shang, M.* “Photoelectrocatalyzed Alkylation of Phosphonites via Direct Decarboxylative C(sp3)-P Coupling” Angew. Chem. Int. Ed. 2025, e202500744.
Yuan, K.-N.; Zhuang, H.; Wei, J.; Shen, Y.; Yao, H.-Q.; Li, M.-H.; Xu, L.-L.; Shang, M.* “Photoelectrochemical Decarboxylative C(sp3)–N Coupling: A Modular Access to Saturated Bioisosteres of Anilines” Nat. Commun. 2025, 16, 920.
Wang, J.-B.; Shen, Y.; Yan, Q.-L.; Kong, W.-J.;* Nian, Y.;* Shang, M.* “Modular Access to C2'-Aryl/Alkenyl Nucleosides with Electrochemical Stereoselective Cross-Coupling” Angew. Chem. Int. Ed. 2025, e202418806.
Liu, X-T.; Cai, Y.-M.; Ban, S.-R.; Shang, M.* “Energy Transfer Enabled Radical Deoxygenative C(sp3)-N Construction” ChemCatChem. 2025, e00317.
Fang, S.-S.; Hu, X.; Li, M.-H.; Qi, S.; Xie, T.; Wang, J.-B.; Yao, H.-Q.; Zhang, J.; Zhang, J.-H.;* Zhu, L.;* Shang, M.* Ligand-Enabled Cu-Catalyzed Stereoselective Synthesis of P-Stereogenic ProTides. J. Am. Chem. Soc. 2024, 146, 31339-31347.
Cai, Y.-M.; Liu, X.-T.; Xu, L.-L.; Shang, M.* “Electrochemical Ni-Catalyzed Decarboxylative C(sp3)-N Cross-Electrophile Coupling” Angew. Chem. Int. Ed. 2024, e202315222.
Sun, S.-Z.; Cai, Y.-M.; Zhang, D.-L.; Wang, J.-B.; Yao, H.-Q.; Rui, X.-Y.; Martin, R.; Shang, M.* “Enantioselective Deaminative Alkylation of Amino Acid Derivatives with Unactivated Olefins” J. Am. Chem. Soc. 2022, 144, 1130.
