
张雁
Yan Zhang
上海交通大学 生命科学技术学院院长,特聘教授
2023年新基石研究员
2021年国家杰出青年基金
Email:
主要学习经历
2001.06-2006.12: University of Pennsylvania, School of Medicine 细胞与分子生物学,遗传学博士
2000.09-2001.06: Wayne State University,School of Medicine,生物化学,博士研究生
1992.09-1996.07:南京大学,生物系,植物学学士
研究工作经历
2024.04-至今:上海交通大学生命科学技术学院,特聘教授,博士生导师;
2022.01-2024.04:天津大学药物科学与技术学院,讲席教授,二级教授,博士生导师;
2018.12-2021.12:天津大学药物科学与技术学院,教授,博士生导师,北洋学者;
2014.10-2018.12: 天津大学药物科学与技术学院,副教授,博士生导师,北洋学者;
2013.09-2014.09: R&D Systems Inc. Minneapolis, USA 资深科学家, 领导团队成功开发了十几种不同家族的酶以及相关试剂盒产品;
2008.10-2012.12: Massachusetts Institute of Technology 博士后和研究科学家(Research Scientist),麻省理工学院化学系, 师从美国科学院资深院士、美国国家科学勋章得主JoAnne Stubbe教授;
2006.12--2008.9, 2013.5-2013.9: University of Pennsylvania, School of Medicine, 宾夕法尼亚大学, 博士后。
获得荣誉
1992 汕头市友华奖学金
2001 Thomas Rumble Fellowship
2001-2006 Graduate Fellowship
2013 National Research Service Award.
2014年 天津大学北洋学者
2015年 天津市青年千人
2015 Grant of the year award, SPST, TJU
2017 Excellent Supervisor Award, 1st ACS Jingjinji Chapter Young Star Forum on Health Science
2018 Publication of the year award, SPST, TJU
2018年 天津大学教工先锋
2019年 天津市创新人才推进计划中青年科技创新领军人才
2021年 国家自然科学杰出青年基金
2023年 入选新基石研究员项目
2023年 国家级教学成果二等奖 排名第六
2025年 教育部高等学校自然科学研究优秀成果奖一等奖 排名第一
主持或参加科研项目及人才计划项目情况
新基石科学基金会“新基石研究员项目”(NCI-202321),2023-12-2028-12,2500万,在研,主持;
上海市市级科技重大专项课题“重大药物和材料的化学赋能合成生物创制”,子课题“不饱和聚酯原料1,2-丙二醇的生物制造” (24Z510305050),2025-05-2029-03,100万,在研,子课题负责人;
微生物代谢全国重点实验室自主研究重点课题“厌氧微生物初级代谢途径的发现”(SKLMMZD_01),2025-06-2027-07,100万,课题负责人;
天津大学自主创新基金“2023合成生物学前沿科学中心建设”(2023XJD-0078),2023-01-2023-12,20万,结题,主持;
自然科学基金京津冀基础研究合作专项 “合成生物学肠道菌使能技术干预和治疗痛风”, (22JCZXJC00150),2022-10-2025-09, 60万,在研,主持;
天津大学自主研发成果基金 (No. 2022XCG-0006), TJU. 2022-01-2022-12, 30万,结题,主持;
国家自然科学杰出青年基金 微生物初级代谢。(32125002), 2021-12-2025-12,400万,在研,主持;
天津大学自主基金“人才团队-科技领军人才”(No. 2021XJQ-0004) 2021-09-2021-12,50万,结题,主持;
天津大学自主创新基金“合成生物学前沿科学建设中心”(2021XY-0005),2021-01-2021-12,20万,结题,参加;
天津大学自主研发挑战基金 (No. 2021XY-0004) 2021-01-2021-12, 10万,结题,主持;
天津市“项目+团队”重点培养专项。2020-12-2023-12,60万,在研,主持;
科技部国家重点研发计划“合成生物学”专项,2020YFA0907900,“重要植物天然产物的途径构建”,1900万,2020-11至2025-10,项目骨干,54.7万,在研,参加;
天津市合成生物技术创新能力提升行动产业关键技术孵化项目专项,TSBICIP-CYFH-001, “抗突变型瓜氨酸波形蛋白抗体类风湿关节炎诊断”,2020-2023,160万,在研,主持;
科技部国家重点研发计划“合成生物学”专项,2019YFA0905700,“新天然与人工产物的定向挖掘和高效合成的平台技术”,1943万,2020-01-2024-12,在研, 课题二“人工产物的定向挖掘和高效合成的平台技术”,437万,在研,主持;
天津大学自主基金科技成果转化 (No. 2020XT-0030) 2020-01-2020-12, 5万,结题,主持;
自然科学基金面上项目,项目号31870049“甘氨酸自由基酶IseG在肠道菌群C、N、S和能量代谢中作用的研究”,2019 -2022,59万,结题,主持;
自然科学基金面上项目,项目号31570060“甘氨酸自由基酶YjjI在DNA修复中作用及其酶促反应机理研究”,2016 -2020,65万,结题,主持;
天津市青年千人,2016年,50万,生物医学,主持;
天津大学北洋学者,2015年,200万,主持;
深圳市海外高层次人才创新创业计划“双特异性抗Tn-型糖基化Muc1抗体在癌症诊断上的应用”,2018-2021,100万,主持;
美国国家卫生院(NIH)Ruth L. Kirschstein T32 training grant, National Research Service Award,2013-2014,5.2万美元,主持;
美国国家卫生院(NIH)RO1研究课题GM81393,2008-2012,187万美元,主要参与人;
美国国家卫生院(NIH)RO1研究课题GM29595,2008-2012,193万美元,主要参与人;
美国国家卫生院(NIH)RO1研究课题 DK53953,2001-2006,217万美元,主要参与人。
学术论文
Liu X, Hu Y, An J, Zhang C, Wei Y*, Zhang Y*. A pathway for D-cysteinolate degradation in sulfate- and sulfite-reducing bacteria. J Biol Chem. 2025 Dec 13. DOI: 10.1016/j.jbc.2025.111055.
Yang Q#, Zhang L#, Liang Y#, Ma H, Song L, Luo L, Tan J, Hu Y, Ma K, Chen Y, Tong Y, Zhang C, Zhao S*, Wang M*, Zhang L*, Wei Y*, Zhang Y*. Carboxymethylcytosine is a natural base modification and a handle for bacteriophage DNA hypermodification. Nature Communications. 2025 Dec 07. DOI: 10.1038/s41467-025-66999-9.
Yang S, Wang K, Hu Y, Zhang L, Zhang C, Liu Y, Li Z, Jiang L, Han Y, Naowarojna N*, Wei Y*, Zhang Y*. Studies on Two Convergently Evolved Cysteate Synthases in Sulfonolipid Biosynthesis. ACS Chem. Biol. 2025 Oct 30. DOI: 10.1021/acschembio.5c00142.
Li Z#, Meng W#, Gao Z#, Peng W, Hu Z, Zhang J, Wang Y, Wu X, Zhao Z, Zhang C, Tang Z, Nie Z, Wu S, Wu B, Zheng H, Luo D, Tong Y, Hu Y, Hu Z, Wei Y*, Zhang Y*. A reductive uric acid degradation pathway in anaerobic bacteria. Life Metab. 2025 Jul 31;4(6):loaf031. DOI: 10.1093/lifemeta/loaf031.
Liu J, Zhang Y*, Naowarojna N*. Identification and functional characterization of transketolases in sulfoglycolytic pathways. Methods in Enzymology. 2025, 722:175-193.
Zhou Q, Zhao Y, Ke C, Wang H, Gao S, Li H, Zhang Y, Ye Y*& Luo Y*. Repurposing endogenous type I-E CRISPR-Cas systems for natural product discovery in Streptomyces. Nat Commun. 2024 Nov 13;15(1):9833. DOI: 10.1038/s41467-024-54196-z.
Lin L, Wang C, Wang W, Jiang H, Murayama T, Kobayashi T, Hadiatullah H, Chen YS, Wu S, Wang Y, Korza H, Gu Y, Zhang Y, Du J, Petegem FV*, Yuchi Z*. Cryo-EM structures of ryanodine receptors and diamide insecticides reveal the mechanisms of selectivity and resistance. Nat Comm 2024, 15, 9056
Chen Y, Chu R, Ma K, Jiang L, Yang Q, Li Z, Hu M, Guo Q, Lu F*, Wei Y*, Zhang Y*, Tong Y*. Study of sulfoglycolysis in Enterococcus gilvus reveals a widespread bifurcated pathway for dihydroxypropanesulfonate degradation. iScience. 2024, 27(10), 111010 DOI: 10.1016/j.isci.2024.111010.
Ma K, Xue B, Chu R, Zheng Y, Sharma S, Jiang L, Hu M, Xie Y, Hu Y, Tao T, Zhou Y, Liu D, Li Z, Yang Q, Chen Y, Wu S, Tong Y, Robinson RC, Yew WS, Jin X, Liu Y, Zhao H, Ang EL, Wei Y*, Zhang Y*. A Widespread Radical-Mediated Glycolysis Pathway. J Am Chem Soc. 2024 146 (38), 26187-26197 DOI: 10.1021/jacs.4c07718.
Liu C, Ma K, Jiang L, Liu X, Tong Y, Yang S, Jin X, Wei Y*, Zhang Y*. Bacterial cysteate dissimilatory pathway involves a racemase and D-cysteate sulfo-lyase. J Biol Chem. https://doi.org/10.1016/j.jbc.2024.107371. (通讯作者)
Jiang L#, Yang Y#, Huang L, Zhou Y, An J, Zheng Y, Chen Y, Liu Y, Huang J, Ang EL, Zhao S, Zhao H, Liao R*, Wei Y*, and Zhang Y* Glycyl Radical Enzymes Catalyzing the Dehydration of Two Isomers of N -Methyl-4-hydroxyproline. ACS Catal. 2024, March;14, 7, 4407-4422.(通讯作者)
Kang S#, Liu Q#, Zhang J, Zhang Y*, Qi H* 2,6-diaminopurine (Z)-containing toehold probes improve genotyping sensitivity. Biotechnol. Bioeng. 2024 Apr;121(4):1384-1393.(通讯作者)
Liu H, Xiao Q, Wu X, Ma H, Li J, Guo X, Liu Z, Zhang Y, Luo Y* Mechanistic investigation of a D to N mutation in DAHP synthase that dictates carbon flux into the shikimate pathway in yeast. Commun Chem. 2023 Jul 15;6(1):152.
Ye Z#, Wei Y#, Jiang L, Zhang Y* Oxygenolytic sulfoquinovose degradation by an iron-dependent alkanesulfonate dioxygenase. iScience. 2023 Aug 31;26(10):107803.(通讯作者)
Liu X#, Wei Y#, Zhang J, Zhou Y, Du Y, Zhang Y* Isethionate is an intermediate in the utilization of sulfoacetate as a terminal electron acceptor by the human gut pathobiont Bilophila wadsworthia. J Biol Chem. 2023 Aug;299(8):105010.(通讯作者)
Chu R#, Wei Y#, Liu J, Li B, Zhang J, Zhou Y, Du Y, Zhang Y* A variant of the sulfoglycolytic transketolase pathway for the degradation of sulfoquinovose into sulfoacetate. Appl Environ Microbiol. 2023 Jul 26;89(7):e0061723.(通讯作者)
Zhou Y#, Wei Y, Jiang L, Jiao X*, Zhang Y* Anaerobic phloroglucinol degradation by Clostridium scatologenes. mBio. 2023 Aug 31;14(4):e0109923.(通讯作者)
Tong Y#, Wu X#, Liu Y#, Chen H, Zhou Y, Jiang L, Li M*, Zhao S*, Zhang Y* Alternative Z-genome biosynthesis pathway shows evolutionary progression from archaea to phage. Nat Microbiol. 2023, 2023 Jul;8(7):1330-1338.(通讯作者)
Zhou Y#, Wei Y#, Jiang L, Zhang Y*, Jiao X* A (S)-3-hydroxybutyrate dehydrogenase belonging to the 3-hydroxyacyl-CoA dehydrogenase family facilitates hydroxyacid degradation in anaerobic bacteria. Appl Environ Microbiol. 2023 Jun 28;89(6):e0036623.(通讯作者)
Tong Y#, Wei Y#, Ju Y#, Li P, Zhang Y, Li L, Gao L, Liu S, Liu D, Hu Y, Li Z, Yu H, Luo Y, Wang J, Wang Y*, Zhang Y* Anaerobic purinolytic enzymes enable dietary purine clearance by engineered gut bacteria. Cell Chem Biol. 2023, 30, 1-11. (通讯作者)
Zhou S, Wu Y, Zhao Y, Zhang Z, Jiang L, Liu L, Zhang Y, Tang J, Yuan Y* Dynamics of synthetic yeast chromosome evolution shaped by hierarchical chromatin organization. Natl Sci Rev 2023, 10(5), nwad073.
Wei Y*, Tong Y, Zhang Y* New mechanisms for bacterial degradation of sulfoquinovose. Biosci Rep. 2022, 42(10): BSR20220314. (通讯作者)
Zhao F#, Wei Y#, Wang X, Zhou Y, Tong Y, Ang EL, Liu S, Zhao H*, Zhang Y* Enzymatic Synthesis of the Unnatural Nucleotide 2'-Deoxyisoguanosine 5'-Monophosphate. ChemBioChem 2022 Nov 4;23(21):e202200295. (通讯作者)
Duan Y#, Wei Y#, Xing M, Liu J, Jiang L, Lu Q, Liu X, Ang EL, Liao RZ, Yuchi Z*, Zhao H*, Zhang Y* Anaerobic hydroxyproline degradation involving C-N cleavage by a glycyl radical enzyme. J Am Chem Soc 2022, 144, 22, 9715–9722. (通讯作者)
Xu J*, Kerr L, Jiang Y, Suo W, Zhang L, Lao T, Chen Y*, Zhang Y* Rapid antigen diagnostics as frontline testing in the COVID-19 pandemic. Small Science 2022, 2(8), 2200009. (通讯作者)
Zhang Z; Li P, Wang M, Zhang Y, Wu B, Tao Y, Pan G, Chen Y* (S)-3-aminopiperidine-2,6-dione is a biosynthetic intermediate of microbial blue pigment indigoidine. mLife 2022 1(2)146–155.
Li G#, Nanjaraj A.N#, Dancis A* and Zhang Y* Genetic suppressors of Δgrx3 Δgrx4, lacking redundant multi-domain monothiol yeast glutaredoxins, rescue growth and iron homeostasis. Biosci Rep. 2022, 42 (6): BSR20212665. (通讯作者)
Qin J, Zhang J, Lin L, Haji-Ghassemi O, Lin Z, Woycechowsky KJ, Petegem FV, Zhang Y*, Yuchi Z* Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy. eLife 2022;11:e75346. (通讯作者)
Liu Y#, Wei Y#, The TM, Zhou Y, Zhao S, Ang EL, Zhao H*, Zhang Y* Identification and characterization of the biosynthetic pathway of the sulfonolipid capnine. Biochemistry 2022, 61(24): 2861-2869. (通讯作者)
Liu J#, Wei Y#, Ma K#, An J#, Liu X, Liu Y, Ang EL, Zhao H*, Zhang Y* Mechanistically diverse pathways for sulfoquinovose degradation in bacteria. ACS Catal. 2021, 11: 14740-14750. (通讯作者)
Xu J, Jiang J-C, Sun L, Liam Kerr, Paulsson, J, Zhang Y*, Lao T* Handheld microfluidic filtration platform enables rapid, low-cost and robust self-testing of SARS-CoV-2 virus. Small 2021, 17(52):e2104009(通讯作者)
An J#, Wei Y#, Liu J, Ang EL, Zhao H*, Zhang Y* Biochemical investigation of 3-sulfopropionaldehyde reductase HpfD. ChemBioChem 2021, 22(19), 2862-2866(通讯作者)
Zhang H#, Wei Y#, Lin L, Liu J, Chu R, Cao P, Ang EL, Zhao H*, Yuchi Z*, Zhang Y* Structural and biochemical investigation of UTP cyclohydrolase. ACS Catalysis 2021, 11(14), 8895–8901.(通讯作者)
Lu Q#, Wei Y#, Lin L, Liu L, Duan Y, Li Y, Zhai W, Liu Y, Ang EL, Zhao H*, Yuchi Z*, Zhang Y* The glycyl radical enzyme arylacetate decarboxylase from Olsenella scatoligenes. ACS Catal. 2021, 11(9), 5789–5794. (通讯作者)
Ma R#, Ghassemi OH#, Ma D, Jiang H, Lin L, Yao L,Samurkas A, Li Y, Wang Y, Wu S, Zhang Y, Murayama T, Moussian B, Petegem FV*, Yuchi Z* Structural Insights into the Diamide Modulation of Ryanodine Receptor. Biophysical Journal 2021, 120(3), 149a.
Wei Y, Zhang Y* Glycyl Radical Enzymes and Sulfonate Metabolism in the Microbiome. Annual Rev. Biochem. 2021, 90:817-846. (通讯作者)
Zhou Y#, Xu X#, Wei Y#, Cheng Y, Guo Y, Khudyakov I, Liu F, He P, Song Z, Li Z, Gao Y, Ang EL, Zhao H*, Zhang Y*, Zhao S* A widespread pathway for substitution of adenine by diaminopurine in phage genomes. Science 2021, 372(6541):512-516. (通讯作者)
Jiang J-C, Zhang Y* Serological antibody testing in the COVID-19 pandemic: their molecular basis and applications. Biochem Soc Trans. 2020 Dec 18; 48 (6): 2851–2863. (通讯作者)
Liu Y#, Wei Y#, Zhou Y, Ang EL, Zhao H*, Zhang Y* A transaldolase-dependent sulfoglycolysis pathway in Bacillus megaterium DSM 1804. Biochem Biophys Res Comm. 2020, 533(4):1109-1114. (通讯作者)
Ma R#, Ghassemi OH#, Ma D#, Jiang H#, Lin L, Yao L, Samurkas A, Li Y, Wang Y, Cao P, Wu S, Zhang Y, Murayama T, Moussian B, Petegem FV*, Yuchi Z* Structural basis for diamide modulation of ryanodine receptor. Nat Chem Biol. 2020, 16(11):1246-1254.
Wang F#, Wei Y#, Lu Q, Ang EL, Zhao H*, Zhang Y* A ferredoxin-dependent dihydropyrimidine dehydrogenase in Clostridium chromiireducens. Biosci Rep. 2020, 40(7):BSR20201642. (通讯作者)
Liu J#, Wei Y#, Lin L, Teng L, Yin J, Lu Q, Chen J, Zheng Y, Li Y, Xu R, Zhai W, Liu Y, Liu Y, Cao P, Ang EL, Zhao H*, Yuchi Z*, Zhang Y* Two radical-dependent mechanisms for anaerobic degradation of the globally abundant organosulfur compound dihydroxypropanesulfonate. Proc Natl Acad Sci U S A. 2020, 117(27):15599-15608. (通讯作者)入选Faculty of 1000
Zhu D#, Wei Y#, Yin J, Liu D, Ang EL, Zhao H*, Zhang Y*. A pathway for degradation of uracil to acetyl coenzyme A in Bacillus megaterium. Appl & Environ Microbiol. 2020, 86(7):e02837-19. (通讯作者)
Yin J#, Wei Y#, Liu D, Hu Y, Lu Q, Ang EL, Zhao H*, Zhang Y*. An extended bacterial reductive pyrimidine degradation pathway that enables nitrogen release from β-alanine. J Biol Chem. 2019, 294(43): 15662-15671. (通讯作者)
Xing M#, Wei Y#, Hua G, Li M, Nanjaraj Urs AN, Wang F, Hu Y, Zhai W, Liu Y, Ang EL, Zhao H*, Zhang Y*. A gene cluster for taurine sulfur assimilation in an anaerobic human gut bacteria. Biochem J. 2019, 476(15):2271-2279. (通讯作者)
Tong Y#, Wei Y#, Hu Y, Ang EL, Zhao H*, Zhang Y* A pathway for isethionate dissimilation in Bacillus krulwichiae. Appl & Environ Microbiol. 2019, 85(15):e00793-19. (通讯作者)
Zhou Y#, Wei Y#, Nanjaraj A.N., Lin L, Xu T, Hu Y, Ang EL, Zhao H*, Yuchi Z*, Zhang Y*. Identification and characterization of a new sulfoacetaldehyde reductase from the human gut bacterium Bifidobacterium kashiwanohense. Biosci Rep. 2019, 39(6):BSR20190715. (通讯作者)
Li M#, Wei Y#, Yin J, Lin L, Zhou Y, Hua G, Cao P, Ang EL, Zhao H*, Yuchi Z*, Zhang Y*. Biochemical and structural investigation of taurine:2-oxoglutarate aminotransferase from Bifidobacterium kashiwanohense. Biochem J. 2019, 476(11):1605-1619. (通讯作者)
Xing M#, Wei Y#, Zhou Y, Zhang J, Lin L, Hu Y, Hua G, Nanjaraj A.N., Liu D, Wang F, Guo C, Tong Y, Li M, Liu Y, Ang E, Zhao H*, Yuchi Z*, Zhang Y*. Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria. Nat Comms. 2019, 10(1):1609. (通讯作者)
Zhang J#, Nanjaraj A.N. #, Lin L, Yuchi Z*, Zhang Y*. Structure of glycerol dehydrogenase (GldA) from Escherichia coli. ACTA CRYSTALLOGR F. 2019, 75(Pt 3):176-183. (通讯作者)
Zhou Y#, Wei Y#, Lin L, Xu T, Ang E, Zhao H*, Yuchi Z*, Zhang Y*. Biochemical and structural investigation of sulfoacetaldehyde reductase from Klebsiella oxytoca. Biochem J. 2019, 476(4):733-746. (通讯作者)
Liu D#, Wei Y#, Liu X, Zhou Y, Jiang L, Yin J, Wang F, Hu Y, Nanjaraj A.N., Liu Y, Ang E, Zhao S*, Zhao H*, Zhang Y*. Indoleacetate decarboxylase: a new glycyl radical enzyme catalysing the formation of malodorant skatole. Nat Comms. 2018, 9(1):4224. (通讯作者)
Nanjaraj A.N., Hu Y, Li P, Yuchi Z, Chen Y*, Zhang Y*. Cloning and expression of a non-ribosomal peptide synthetase to generate blue rose. ACS Synth. Biol. 2019, 8(8):1698-1704. (通讯作者)
Guo C#, Hu Y#, Yang C, Nanjaraj Urs AN, Zhang Y* Developing a colorimetric assay for Fe(II)/2-oxoglutarate-dependent dioxygenase. Anal Biochem. 2018, 548:109-114. (通讯作者)
Hua G#, Hu Y#, Yang C, Liu D, Mao Z, Zhang L, Zhang Y* Characterization of santalene synthases using an inorganic pyrophosphatase coupled colorimetric assay. Anal Biochem. 2018, 547:26-36. (通讯作者)
Zhang Y, Yang C, Dancis A, Nakamaru-Ogiso E. EPR studies of wild type and mutant Dre2 identify essential [2Fe--2S] and [4Fe--4S] clusters and their cysteine ligands. J Biochem. 2017, 161(1):67-78. (第一作者)
Zhang Y#, Li H#, Zhang C, An X, Liu L, Stubbe J, Huang M. The Conserved Electron Donor Complex Dre2-Tah18 Is Required for Ribonucleotide Reductase Metallocofactor Assembly and DNA Synthesis. Proc Natl Acad Sci U S A. 2014, 111(17):E1695-704. (第一作者)
58.Yoon H, Knight SA, Pandey A, Pain J, Zhang Y, Pain D, Dancis A. Frataxin-bypassing Isu1: characterization of the bypass activity in cells and mitochondria. Biochem J. 2014, 459(1):71-81.
Zhang Y, Liu L, Stubbe J. Huang M. Investigation of in vivo roles of the carboxyl terminal tails of the small subunit (ββ') of S. cerevisiae ribonucleotide reductase: contribution to cofactor formation and inter-subunit association within the active holoenzyme. J Biol Chem. 2013, 288(20):13951-9. (第一作者) Selected as the “Papers of The Week”, representing top 1-2% of JBC publications, Personal profile highlighted at http://www.jbc.org/content/288/20/13960/suppl/DCAuthor_profile
Zhang Y, Liu L, Wu X, An X, Stubbe J , Huang M. Investigation of in vivo diferric tyrosyl radical formation in Saccharomyces cerevisiae Rnr2: requirement of Rnr4 and contribution of Grx3/4 and Dre2. J Biol Chem. 2011, 286(48):41499-509. (第一作者)Selected as the “Papers of The Week”, representing top 1% of JBC publications, Personal profile and research highlighted at http://www.jbc.org/content/286/48/41499/suppl/DCAuthor_profile http://www.asbmb.org/asbmbtoday/asbmbtoday_article.aspx?id=14939
Zhang Y, Stubbe J, Bacillus subtilis Class Ib Ribonucleotide Reductase Is a Dimanganese(III)-Tyrosyl Radical Enzyme. Biochemistry. 2011, 50(25):5615-23. (第一作者)
Mühlenhoff U, Molik S, Godoy JR, Uzarska MA, Richter N, Seubert A, Zhang Y, Stubbe J, Pierrel F, Herrero E, Lillig CH, Lill R. Cytosolic monothiol glutaredoxins function in intracellular iron sensing and trafficking via their bound iron-sulfur cluster. Cell Metab. 2010, 12(4):373-85.
Yoon H, Zhang Y, Pain J, Lyver ER, Lesuisse E, Pain D, Dancis A. Rim2, pyrimidine nucleotide exchanger, is needed for iron utilization in mitochondria. Biochem J. 2011, 440(1):137-46.
Zhang Y, Lyver, ER, Amutha B, Ohnishi, T, Pain, D, and Dancis, A. Dre2, a conserved eukaryotic protein with both [2Fe-2S] and [4Fe-4S] clusters, functions in cytosolic iron-sulfur protein biogenesis. Mol Cell Biol. 2008, 28 (18) 5569-82. (第一作者)
Zhang Y, Lyver, ER, Knight, SAB, Pain, D, Lesuisse, E, and Dancis, A. Mrs3p, Mrs4p, and frataxin provide iron for Fe-S cluster synthesis in mitochondria. J Biol Chem. 2006, 281(32):22493-502. (第一作者)
Zhang Y, Lyver, ER, Knight, SAB, Lesuisse, E, and Dancis, A. Frataxin and mitochondrial carrier proteins, Mrs3p and Mrs4p, cooperate in providing iron for heme synthesis. J Biol Chem. 2005, 280 (20):19794-807. (第一作者)
He Y, Alam SL, Proteasa SV, Zhang Y, Lesuisse E, Dancis A, and Stemmler T.L. Yeast frataxin solution structure, iron binding, and ferrochelatase interaction. Biochemistry. 2004, 43(51):16254-62.
Deshmukh M, May M, Zhang Y, Gabbert KK, Karberg KA, Kranz RG, and Daldal F. Overexpression of ccl1-2 can bypass the need for the putative apocytochrome chaperone CycH during the biogenesis of c-type cytochromes. Mol. Microbiology 2002, 46(4)1069-1080.
专利
用于数据加密的系统、方法和装置。专利申请号:202311054830.8
制备1,2-丙二醇的生物学方法。专利申请号:202311615909.3
用于1,2-丙二醇生物合成的多肽及其用途。专利申请号:202311617289.7
一种基于Z-DNA的信息存储技术。专利号:ZL 2022 1 1067651.3授权号:CN 117672383 B
异鸟嘌呤脱氧核糖核苷酸的制备方法。ZL202210034330.7
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