教育背景

• 1994-1998 湖南大学，学士，腐蚀与防护

• 2000-2003 东华大学，硕士，应用化学

• 2003-2006 中国科学院上海有机化学研究所，博士，有机化学

工作经历

• 2006-2009 匹兹堡大学，博士后，核酸化学

• 2009-2011 佛罗里达大学，博士后，核酸化学生物学

• 2011-2013 中国科学院上海有机化学研究所，副研究员

• 2013-2017 湖南大学化学化工学院，副研究员

• 2015-2017 浙江清华长三角研究院 （兼职），PI

• 2017-至今  上海交通大学医学院附属仁济医院，研究员

研究方向

• 非天然碱基设计与合成

• 功能核酸的构建与生物医学应用

科研项目

• 主持国家自然科学基金面上项目

• 参与科技部重点研发课题

• 浙江省自然科学基金面上项目

代表性论文专著

1. Cai Yang, Haitao Zhao, Yang Sun, Cheng Wang, Xinyao Geng, Ruowen Wang*, Lumin Tang, Da Han, Jianjun Liu* and Weihong Tan*. “Programmable manipulation of oligonucleotide-albumin interaction for elongated circulation time.” Nucleic Acids Res. 2022, ASAP.

2. Fei Gao, Jinming Zhou, Yang Sun, Cai Yang, Shiyan Zhang, Ruowen Wang*, and Weihong Tan*. ‘Programmable Repurposing of Existing Drugs as Pharmaceutical Elements for the Construction of Aptamer-Drug Conjugates’; ACS Appl. Mater. Interfaces 2021, 13, 9457-9463.

3. Kaiming Chen, Jie Zhou, Zhentao Shao, Jia Liu, Jia Song, RuoWen Wang*, Juan Li*, and Weihong Tan*. “Aptamers as Versatile Molecular Tools for Antibody Production Monitoring and Quality Control.” J. Am. Chem. Soc. 2020, 142, 12079-12086.

4. RuoWen Wang, Cheng Jin, Xiaoyan Zhu, Liyi Zhou, Wenjing Xuan, Yuan Liu, Qiaoling Liu, and Weihong Tan*. “Artificial Base zT as Functional “Element” for Constructing Photoresponsive DNA Nanomolecules.” J. Am. Chem. Soc. 2017, 139, 9104-9107.

5. Cheng Jin, Ting Fu, RuoWen Wang*, Hui Liu, Jiamei Zou, Zilong Zhao, Mao Ye, Xiaobing Zhang and Weihong Tan*. “Fluorinated molecular beacons as functional DNA nanomolecules for cellular imaging.” Chem. Sci. 2017, 8, 7082-7086.

6. RuoWen Wang*, Danqing Lu, Huarong Bai, Cheng Jin, Guobei Yan, Mao Ye, Liping Qiu, Rongshan Chang, Cheng Cui, Hao Liang and Weihong Tan*. “Using modified aptamers for site specific protein–aptamer conjugations.” Chem. Sci. 2016, 7, 2157-2161.

7. RuoWen Wang, Chunming Wang, Yang Cao, Zhi Zhu, Chaoyong Yang, Jianzhong Chen, Feng-Ling Qing and Weihong Tan*. “Trifluoromethylated Nucleic Acid Analogues Capable of Self-Assembly through Hydrophobic Interactions.” Chem. Sci. 2014, 5, 4076-4081.

8. RuoWen Wang, Guizhi Zhu, Lei Mei, Yan Xie, Mao Ye, Feng-Ling Qing and Weihong Tan*. “Automated and Modular Synthesis of Aptamer-Drug Conjugates for Targeted Drug Delivery.” J. Am. Chem. Soc. 2013, 136, 2731-2734.

9. Ruo-Wen Wang and Barry Gold*. “A Facile Synthetic Approach to 7-Deazaguan-ine Nucleosides via a Boc Protection Strategy.” Org. Lett., 2009, 11, 2465–2468.

10. Ruo-Wen Wang, Xiao-Long Qiu, Mikael Bols, Fernando Ortega Caballero and Feng-Ling Qing*. “Synthesis and Biological Evaluation of Glycosidase Inhibitors: gem-Difluoro-Methylenated Nojirimycin Analogues.” J. Med. Chem. 2006; 49, 2989.